What cards are you considering getting? You'd have to use the included molex to PCI-e adapters that come with your cards but for everything but the X1900 series and 7900GTX series and up cards you should be fine.
Phenom II 940 Black Edition quad core @ 3.5Ghz
4x2 Gigs Patriot PC2 6400
Cooler Master HAF XB EVO,
Some other stuff,
Even more stuff,
If the automobile had followed the same development cycle as the computer, a Rolls-Royce would today cost $100, get a million miles per gallon, and explode once a year, killing everyone inside. --Robert X. Cringely, InfoWorld magazine